Efficacy, safety, and biomarkers of neoadjuvant trastuzumab and pertuzumab combined with chemotherapy in Chinese patients with HER2-positive breast cancer: a multicenter retrospective cohort study
Trastuzumab and pertuzumab combined with different chemotherapy regimens demonstrated high tpCR rates and manageable safety in HER2-positive breast cancer, particularly in HER2-positive HR-negative patients. The study supports the real-world efficacy of dual HER2-targeted neoadjuvant therapy, though further validation of biomarkers and long-term outcomes is needed.
Authors
- Jun Jiang (ORCID: https://orcid.org/0000-0001-9408-2972)
- Sihai Zhou (ORCID: https://orcid.org/0009-0004-2889-2570)
- Shushu Wang (ORCID: https://orcid.org/0000-0001-6343-8585)
- Hong Hu (ORCID: https://orcid.org/0000-0002-5427-6040)
- Yan Xu (ORCID: https://orcid.org/0000-0001-5681-0908)
- Xiaochun Wang (ORCID: https://orcid.org/0000-0002-3216-5710)
- Yanman Fang
- Jia Ming (ORCID: https://orcid.org/0000-0001-5256-0307)
- Xiaowei Qi (ORCID: https://orcid.org/0000-0002-5876-4957)
- Shu Liu (ORCID: https://orcid.org/0009-0000-2914-1091)
- Qiyun Shi (ORCID: https://orcid.org/0000-0003-3062-8846)
- Mengyuan Wang (ORCID: https://orcid.org/0000-0002-8958-5943)
- Pengfei Qiu (ORCID: https://orcid.org/0000-0001-8644-1445)
- Taolang Li (ORCID: https://orcid.org/0000-0001-8150-7687)
- Yongsheng Wang (ORCID: https://orcid.org/0000-0001-6252-684X)
- Li Chen (ORCID: https://orcid.org/0000-0002-8607-8997)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-8042-7957)
- Wenlin Chen (ORCID: https://orcid.org/0000-0003-4687-2384)
- Jianyun Nie (ORCID: https://orcid.org/0000-0003-3691-8940)
- Yuanming Fan
- Fan Chai
- Yueyang Liang (ORCID: https://orcid.org/0000-0002-1563-0596)
- Peng Tang (ORCID: https://orcid.org/0009-0007-0301-1134)
Institutions
- Guiyang Medical University (CN)
- Army Medical University (CN)
- Shandong University (CN)
- Zunyi Medical University (CN)
- Dalian Medical University (CN)
- Kunming Medical University (CN)
- Chinese PLA General Hospital (CN)
- Daping Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Shandong Tumor Hospital (CN)
- Guizhou Cancer Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guiyang University (CN)
- Third People 's Hospital of Chongqing (CN)
- Chongqing Three Gorges Central Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Affiliated Hospital of Hebei University (CN)
- First People's Hospital of Chongqing (CN)
- Shandong First Medical University (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1097/js9.0000000000003551
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00