Disparities in the receipt of palliative-intent treatment amongst disaggregated Hispanic populations with stage IV liver cancer in the United States.

118 Background: Palliative-intent treatment improves the quality of life and survival of patients, yet disparities still exist. These inequalities have been characterized across racial, socioeconomic, and geographical categories. While previous studies call for increased representation of Hispanic patients in research, few have examined the disparities among subgroups. We identify inequities in the receipt of palliative-intent treatment among disaggregated Hispanic patients with stage IV liver cancer. Methods: We analyzed data from the National Cancer Database (2004-2021) for disaggregated Hispanic patients (Mexican, Puerto Rican, Cuban, Central or South American, Dominican, other Hispanic origin, non-assigned Spanish origin, and Spanish-surname only) diagnosed with AJCC stage IV liver cancer. Disparities in the use of palliative-intent intervention between Hispanic subgroups were quantified by multivariate linear regressions. Results: Among 37,894 total cancer patients, 6,557 (17.3%) patients received palliative-intended treatment. Compared to non-Hispanic white patients, disaggregated analyses revealed reduced receipt of palliative-intent interventions for patients with liver cancer of Mexican descent (AOR 0.69, [0.54-0.89], P<0.01). Palliative interventions for liver metastatic cancer were reduced for patients of Cuban descent compared to non-Hispanic white patients (8.3% vs. 18.1%, P > 0.05). Conclusions: Our study highlights the significant disparities in receipt of palliative-intent care amongst Hispanic subgroups upon disaggregation, underscoring the need for continued disaggregated research and targeted community- and patient-level solutions to close care gaps. Odds ratio table for disaggregated patients with liver cancer. Covariate Odds ratio Std. err. z P>|z| 95% conf. interval] Race/Ethnicity: (Ref: non-Hispanic White) Mexican 0.69 0.09 -2.84 0.00 0.53 0.89 Puerto Rican 0.83 0.14 -1.15 0.25 0.60 1.14 Cuban 0.44 0.19 -1.90 0.06 0.19 1.02 South/Central American 0.90 0.16 -0.60 0.55 0.63 1.28 Other Hispanic 0.90 0.24 -0.39 0.70 0.54 1.51 Non-Assigned Spanish 0.77 0.05 -4.43 0.00 0.69 0.87 Spanish surname only 0.38 0.17 -2.11 0.04 0.15 0.93 Dominican Republic 0.72 0.25 -0.96 0.34 0.36 1.42 Unknown 0.94 0.03 -1.85 0.06 0.88 1.00 Median Income Quartiles for 2016 (Ref: <$40,227) $40,227 - $50,353 1.07 0.04 1.71 0.09 0.99 1.15 $50,354 - $63,332 0.99 0.04 -0.31 0.76 0.91 1.07 ≥$63,333