Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination
Our findings provide in vivo evidence for exaggerated innate and attenuated adaptive immune responses to vaccination in SMI patients. The study underscores the need for longitudinal, experimental approaches in immunopsychiatry to better characterise the dynamic dysregulation of both the innate and the adaptive immune system in this population.
Authors
- Manuel Morrens (ORCID: https://orcid.org/0000-0003-4559-3666)
- Ryad Tamouza (ORCID: https://orcid.org/0000-0003-3992-9565)
- Jean‐Romain Richard (ORCID: https://orcid.org/0000-0001-6332-6890)
- Steven D.E. Fried (ORCID: https://orcid.org/0000-0002-4826-2451)
- Marion Leboyer (ORCID: https://orcid.org/0000-0001-5473-3697)
- Violette Coppens (ORCID: https://orcid.org/0000-0001-6247-551X)
- Alexandre Lucas (ORCID: https://orcid.org/0000-0002-2736-9946)
- Kawtar El Abdellati
- Livia De Picker (ORCID: https://orcid.org/0000-0002-6883-0559)
- Margot Lemarinier
- Tim Rietberg
Institutions
- University of Antwerp (BE)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Fondation FondaMental (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bbih.2025.101114
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00