Targeting transglutaminase 2: pathways to celiac disease therapies
Active-site-directed inhibitors, LDN27219 and knockdown of TG2 expression significantly reduced extracellular TG2 activity and represent potential alternative treatment targets in the context of CD.
Authors
- Silvia Rudloff (ORCID: https://orcid.org/0000-0001-6143-963X)
- Sebastian Stricker (ORCID: https://orcid.org/0000-0003-1531-3627)
- Klaus‐Peter Zimmer
- Jan de Laffolie
- Alexandra Endrizzi
- Pauline Grunst
Institutions
- Justus-Liebig-Universität Gießen (DE)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf086
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Justus Liebig Universität Gießen
- University of Oxford
- Deutsche Forschungsgemeinschaft
- Sun Yat-sen University