High-fat diet induced obesity and anti-activin receptor antibody: Effects on bone properties in mice
αActRIIA/IIB ab enhanced trabecular bone properties in standard chow-fed mice, but its anabolic effects were blunted in HFD-fed mice. Furthermore, αActRIIA/IIB ab improved cortical histological bone formation markers, while morphology remained unaffected, suggesting a site- or time-specific difference. Thus, αActRIIA/IIB ab holds potential for mitigating weight-loss-associated bone deterioration.
Authors
- Christian Brix Folsted Andersen (ORCID: https://orcid.org/0000-0001-6182-2436)
- Jesper Skovhus Thomsen (ORCID: https://orcid.org/0000-0001-9386-6679)
- Frederik Duch Bromer (ORCID: https://orcid.org/0000-0002-6839-139X)
- Annemarie Brüel (ORCID: https://orcid.org/0000-0003-4833-0888)
- Lykke Sylow (ORCID: https://orcid.org/0000-0003-0905-5932)
- Michala Carlsson (ORCID: https://orcid.org/0000-0001-7222-6912)
- Andreas Lodberg (ORCID: https://orcid.org/0000-0001-9261-8753)
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Bone Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bonr.2025.101878
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00