Efficient optimization and synthesis of diverse azaarenes <i>via</i> nitrogen atom insertion under continuous flow conditions
We report the development of a continuous flow approach to nitrogen atom insertion. The setup is modular, enabling the rapid optimization of reaction conditions for a wide range of substrates. The milder reaction conditions led to an improved substrate scope and functional group tolerance compared to batch conditions. The reactions can also be safely scaled up to preparative scale.
Authors
- Thomas C. Fessard (ORCID: https://orcid.org/0000-0001-7939-7861)
- Julia C. Reisenbauer (ORCID: https://orcid.org/0000-0001-5995-5619)
- Quentin Lefebvre (ORCID: https://orcid.org/0000-0003-0307-1966)
- Nancy J. Brenner (ORCID: https://orcid.org/0009-0008-8374-8722)
- Sooyeon Moon (ORCID: https://orcid.org/0000-0003-1638-374X)
- Bill Morandi (ORCID: https://orcid.org/0000-0003-3968-1424)
- Ann-Sophie K. Paschke (ORCID: https://orcid.org/0009-0000-4918-1840)
- Alessandro Scotto
- Luca Terraneo
Institutions
- ETH Zurich (CH)
- Philochem (Switzerland) (CH)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03194j
- Citations
- 2
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 1.87