Cancer-associated venous thromboembolism and its impact on survival in the ONCOTHROMB12-01 cohort study
Cancer patients are at increased risk of venous thromboembolism (VTE), representing one of the main causes of death. In this paper, we used the ONCOTHROMB12-01 study cohort for the analysis of 18-month overall survival (OS) and cancer-associated venous thrombosis (CAT) cumulative incidence. The OS is described for patients with and without CAT across age, sex, cancer type, stage and presence of recurrent VTE using the Kaplan-Meier method and log-rank test. Moreover, a Cox regression model with stepwise feature selection is trained to identify predictors of prognosis. Results show an 18-month CAT cumulative incidence of 16.5 % (CI 13.1-21.0 %) and a median OS for patients with CAT of 9.1 months (CI 5.9-12.5). Furthermore, CAT is associated with shorter survival in lung, colorectal and pancreatic cancer in advanced stages, regardless of age and sex; VTE recurrence also reduces survival significantly. The model found ECOG performance status of 2, cancer type, metastatic stage, VTE, mucinous histology and complete tumor resection as meaningful predictors; the latter being the only protective factor. In conclusion, the diagnosis of CAT has a profound impact on OS in the ONCOTHROMB12-01 study regardless of the clinical characteristics of patients.
Authors
- Ana Rupérez (ORCID: https://orcid.org/0000-0003-2338-4257)
- E. Martínez (ORCID: https://orcid.org/0000-0002-4791-5385)
- Oriol Pujol (ORCID: https://orcid.org/0000-0001-7573-009X)
- Laura Ortega (ORCID: https://orcid.org/0000-0003-0456-7322)
- Bárbara Lobato-Delgado (ORCID: https://orcid.org/0000-0001-6218-5774)
- José Manuel Soria (ORCID: https://orcid.org/0000-0002-6226-4293)
- Virginia Martínez-Marín
- Mercedes Salgado Fernández (ORCID: https://orcid.org/0000-0003-4134-1509)
- Vanessa Pachón
- Victoria Castellón
- Carme Font (ORCID: https://orcid.org/0000-0002-3547-7373)
- Julia Calzas (ORCID: https://orcid.org/0000-0002-9416-9514)
- Magdalena Ruiz (ORCID: https://orcid.org/0000-0002-8853-4984)
- Andrés Muñoz
Institutions
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Clínic de Barcelona (ES)
- Spanish Society of Hematology and Hemotherapy (ES)
- Hospital Universitario de Fuenlabrada (ES)
- Complejo Hospitalario Torrecárdenas (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
- Complejo Hospitalario de Ourense (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.ijcha.2025.101754
- Citations
- 1
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.87