Exploring the Interplay of PI3K/AKT/mTOR and JNK Signaling Pathways in Psoriasis: Insights from Systematic Review and Network Pharmacology Approach
This comprehensive review underscores the importance of the PI3K/AKT/mTOR and JNK pathways in understanding psoriasis mechanisms. Targeting these pathways with flavonoids may offer promising therapeutic strategies by modulating key molecular hubs involved in disease progression.
Authors
- Elisa Zavattaro (ORCID: https://orcid.org/0000-0003-4537-3014)
- Masoud Sadeghi (ORCID: https://orcid.org/0000-0002-3586-3012)
- Samira Ranjbar
- Reza Khodarahmi (ORCID: https://orcid.org/0000-0002-2474-5037)
- Masomeh Mehrabi (ORCID: https://orcid.org/0000-0002-5041-3810)
- Pantea Mohammadi (ORCID: https://orcid.org/0000-0002-0015-4320)
- Seyedeh Zahra Mirzaei
- Ali Ebrahimi (ORCID: https://orcid.org/0000-0002-1900-8323)
- Sasan Shabani
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Kermanshah University of Medical Sciences (IR)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.2174/0113892010380506250909114143
- Citations
- 3
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 2.39