Neuroblastic Tumor Causing Toe-Walking Without Mechanical Compression of the Spinal Cord or Nerve Roots
We describe two children with peripheral neuroblastic tumors (PNTs; ganglioneuroma and ganglioneuroblastoma) remote from neural structures.They presented with toe-walking, ankle contractures, and pes cavus.In both cases, symptoms resolved after resection of the PNT and without orthopedic intervention.These cases highlight that PNTs can cause toe-walking, even without compression of neural structures, and should be considered in the differential diagnosis of toe-walking in children. CasesCase one is a three-year-old male with a history of chronic diarrhea, who developed toe-walking at the age of 2 years.On examination, he toe-walked and had bilateral pes cavus, restricted ankle dorsiflexion, and lower limb hyporeflexia.
Authors
- Eppie M. Yiu (ORCID: https://orcid.org/0000-0001-6704-8402)
- Andrew J. Kornberg (ORCID: https://orcid.org/0000-0003-3985-9472)
- Tom O’Neill (ORCID: https://orcid.org/0000-0002-8336-5763)
Institutions
- Royal Children's Hospital (AU)
Publication Details
- Journal
- Pediatric Neurology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.pediatrneurol.2025.09.010
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00