Neuroblastic Tumor Causing Toe-Walking Without Mechanical Compression of the Spinal Cord or Nerve Roots

We describe two children with peripheral neuroblastic tumors (PNTs; ganglioneuroma and ganglioneuroblastoma) remote from neural structures.They presented with toe-walking, ankle contractures, and pes cavus.In both cases, symptoms resolved after resection of the PNT and without orthopedic intervention.These cases highlight that PNTs can cause toe-walking, even without compression of neural structures, and should be considered in the differential diagnosis of toe-walking in children. CasesCase one is a three-year-old male with a history of chronic diarrhea, who developed toe-walking at the age of 2 years.On examination, he toe-walked and had bilateral pes cavus, restricted ankle dorsiflexion, and lower limb hyporeflexia.

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Publication Details

Journal
Pediatric Neurology
Published
2025-09-22
DOI
https://doi.org/10.1016/j.pediatrneurol.2025.09.010
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Neuroblastic Tumor Causing Toe-Walking Without Mechanical Compression of the Spinal Cord or Nerve Roots

Eppie M. Yiu, Andrew J. Kornberg, Tom O’Neill
Pediatric Neurology
Neuroblastoma Research and Treatments
article

Neuroblastic Tumor Causing Toe-Walking Without Mechanical Compression of the Spinal Cord or Nerve Roots

Eppie M. Yiu, Andrew J. Kornberg, Tom O’Neill
article en

Abstract

We describe two children with peripheral neuroblastic tumors (PNTs; ganglioneuroma and ganglioneuroblastoma) remote from neural structures.They presented with toe-walking, ankle contractures, and pes cavus.In both cases, symptoms resolved after resection of the PNT and without orthopedic intervention.These cases highlight that PNTs can cause toe-walking, even without compression of neural structures, and should be considered in the differential diagnosis of toe-walking in children. CasesCase one is a three-year-old male with a history of chronic diarrhea, who developed toe-walking at the age of 2 years.On examination, he toe-walked and had bilateral pes cavus, restricted ankle dorsiflexion, and lower limb hyporeflexia.

Pediatric NeurologyVol. 173
Royal Children's Hospital (AU)
Openalex Percentile: Top 60%
Neuroblastoma Research and Treatments
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