ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report
ALK-rearranged renal cell carcinoma (<i>ALK-</i>RCC) is a rare subtype of RCC. In this report we describe the first <i>ALK-</i>RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed <i>ALK</i> rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.
Authors
- Shuanzeng Wei (ORCID: https://orcid.org/0000-0002-0441-6973)
- James Ryan Mark (ORCID: https://orcid.org/0000-0001-7675-3437)
- Matthew R. Zibelman (ORCID: https://orcid.org/0000-0003-1475-6477)
- Hafiz A Yahya (ORCID: https://orcid.org/0000-0001-8915-5508)
- Jianming Pei
- Gabriel J DiNatale
- Muntha Chaudhari
- Arthur S. Patchefsky
- Iryna Mahan
Institutions
- Shalamar Hospital (PK)
- Temple University Health System (US)
Publication Details
- Journal
- Urology Case Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.eucr.2025.103219
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00