Research Advances of Extrachromosomal Circular <scp>DNA</scp> in Breast Cancer
The development of ecDNA-targeted therapies and their integration with immunotherapy strategies offers promising new avenues for breast cancer treatment. Despite challenges such as incomplete elucidation of mechanisms, standardization of detection methods, and ethical considerations, ecDNA remains a valuable biomarker and therapeutic target in breast cancer. Future research is anticipated to advance its clinical transformation and application in individualized treatment.
Authors
- Chunhui Jin (ORCID: https://orcid.org/0000-0002-8795-9542)
- Shixia Gong
- Jiahui Li (ORCID: https://orcid.org/0000-0002-4889-0714)
- Xiaodan Zhu
- Yuqing Geng (ORCID: https://orcid.org/0009-0004-7871-7594)
- Yunzhe Qian (ORCID: https://orcid.org/0009-0004-8634-605X)
- Quan Tang (ORCID: https://orcid.org/0009-0002-3870-8082)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Wuxi Taihu Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/cam4.71285
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University