Comparative Efficacy of Magnesium and Potassium Towards CKMB and Quality of Life in Type 2 Diabetes Mellitus Patients

Cardiovascular diseases like myocardial infarction and acute coronary syndrome are common complications in diabetes that can be diagnosed by performing various lab tests, like the Creatine Kinase Myocardial Band (CKMB) test, which is used to evaluate the cardiovascular risks in patients. Objectives: To compare the effects of magnesium and potassium supplementation on CKMB levels and quality of life in type 2 diabetes mellitus patients, focusing on their role in electrolyte balance and cardiovascular risk reduction. Methods: A randomized controlled trial (single-blind) was conducted at Lahore Garrison University, Lahore. Additionally, parameters related to diabetes management, such as blood glucose levels, HbA1c levels, magnesium, and potassium, were also evaluated. The study comprised 80 patients asked to check the effect of magnesium and potassium before and after a two-month dose of two months. Four groups were formed named T1, T2, T3, and T4, which were given a placebo, magnesium, potassium, and a combination of magnesium-potassium, respectively. Results: The Mean age of the participants was 49.675 ± 10.8660. Out of 80 participants, 28 (35%) were female and 52 (65%) were male. Potassium supplements significantly lowered the CKMB value in Type 2 Diabetes Mellitus (T2DM) patients, with the largest decrease in the T3 group. Quality of life was also improved significantly after using supplementation. Conclusions: The treatment positively affected the level of CKMB in the T3 group, which was provided with potassium supplements, suggesting that potassium is effective for lowering the CKMB values. This means that this supplement minimizes the risk of cardiac problems in T2DM.