Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance

Based on the data from this study, poor in vitro susceptibility rates for amikacin and meropenem-vaborbactam against contemporary ceftazidime-avibactam-resistant non-CP-CRE were observed. In contrast, aztreonam-avibactam, colistin and tigecycline appear to be reasonable options for the management of infections caused by ceftazidime-avibactam-resistant non-CP-CRE.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2025-09-23
DOI
https://doi.org/10.1093/jac/dkaf375
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
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article

Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance

I-Min Liu, Chih‐Cheng Lai, Po-Chuen Hsieh, Chia‐Ying Liu et al.
Journal of Antimicrobial Chemotherapy
Antibiotic Resistance in Bacteria
article

Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance

I-Min Liu, Chih‐Cheng Lai, Po-Chuen Hsieh, Chia‐Ying Liu, Yu-tsung Huang, Kang Huang, Shio‐Shin Jean
article en

Abstract

Based on the data from this study, poor in vitro susceptibility rates for amikacin and meropenem-vaborbactam against contemporary ceftazidime-avibactam-resistant non-CP-CRE were observed. In contrast, aztreonam-avibactam, colistin and tigecycline appear to be reasonable options for the management of infections caused by ceftazidime-avibactam-resistant non-CP-CRE.

Journal of Antimicrobial ChemotherapyVol. 80(12)
National Sun Yat-sen University (TW), Min Sheng General Hospital (TW), Tajen University (TW), Far Eastern Memorial Hospital (TW), National Taiwan University Hospital (TW), Chi Mei Medical Center (TW), Lunghwa University of Science and Technology (TW)
Openalex Percentile: Top 77%
Antibiotic Resistance in Bacteria
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Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance — I-Min Liu, Chih‐Cheng Lai, et al. · Journal of Antimicrobial Chemotherapy (2025) | TGRS Research Map | TGRS