Assessment of the level of serum Vitamin D in Chronic Rhinosinusitis.

Background: The paranasal sinuses inflammation that lasts for twelve weeks is known as chronic rhinosinusitis (CRS). There is little mortality from CRS, but the disease has a heavy financial toll and negative effects on people's quality of life. Proposed explanations for this sinonasal mucosa chronic inflammation include ostiomeatal complex blockage, poor mucociliary clearance, nasal microbiota distortion, biofilm development, and atopy, however the precise causes remain unknown. Potent steroid hormone vitamin D regulates calcium homeostasis and bone mineralization. Furthermore, vitamin D has several anti-infectious and anti-inflammatory characteristics and may enhance immune responses. Aim: This work was conducted to assess the levels of serum Vitamin D in patients with CRS and to determine the significance and relationship of these levels with CRS severity and disease outcomes. Methods: This case control study included 100 participants; they were classified into two groups: Group (A) contain 50 patients (26 males and 24 females) with CRS. The range of their ages from 18 to 50 years, with a mean of 35±10.6 years, Group (B) comprised 50 healthy volunteers (25 males and 25 females) as controls. The range of their ages from 23 to 50 years, with a mean of 34.8± 9.6 years. Results: According to this study, controls had significantly greater vitamin D levels than CRS sufferers (P-value<0.001). Additionally, the study demonstrated a substantial correlation (P-value<0.05) between the presence of nasal polyposis and vitamin D levels. Conclusion: According to this research, Serum vitamin D levels are significantly associated with chronic rhinosinusitis (CRS). The results raise the possibility that vitamin D insufficiency contributes to CRS pathophysiology