Effectiveness and safety of upadacitinib in a real-world cohort of patients with Crohn’s disease in the UK: a multicentre retrospective cohort study

This is a large real-world study reporting outcomes in patients with CD treated with upadacitinib. Our data demonstrated good short-term effectiveness and tolerance in a clinically refractory population.

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Publication Details

Journal
BMJ Open Gastroenterology
Published
2025-10-01
DOI
https://doi.org/10.1136/bmjgast-2025-001916
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness and safety of upadacitinib in a real-world cohort of patients with Crohn’s disease in the UK: a multicentre retrospective cohort study

Thomas Morris, Christopher A Lamb, Christian Selinger, Lucy Hicks et al.
BMJ Open Gastroenterology
Inflammatory Bowel Disease
article

Effectiveness and safety of upadacitinib in a real-world cohort of patients with Crohn’s disease in the UK: a multicentre retrospective cohort study

Thomas Morris, Christopher A Lamb, Christian Selinger, Lucy Hicks, Chaonan Dong, Yaa Danso, Anjan Dhar, Kenneth R. Butler, Chandni Radia, Paul Harrow, Kamal Patel, Mohammed Allah-Ditta, Mark Samaan, Lushen Pillay, Xin Yi Choon, Philip Harvey, Klaartje Bel Kok, Nicholas Burr, Richard Pollok, Konstantina Rosiou, Tim Raine, Jie Han Yeo, Fiona Rees, Emma L. Johnston, Puneet Chhabra, Alexandra Kent, Katie Yeung, Polychronis Pavlidis, Sara McCartney, Ally Speight, Charlie W. Lees, Jens Toft, Jimmy K. Limdi, Dania Al-Zarrad, Hannah Trodden-Mittnacht, Karishma Sethi-Arora, Chirag Patel, A Elford, Susan Ritchie, Melissa F Hale, Alice Hewitt, Ruth Rudling, Sonia Kalyanji
article en

Abstract

This is a large real-world study reporting outcomes in patients with CD treated with upadacitinib. Our data demonstrated good short-term effectiveness and tolerance in a clinically refractory population.

BMJ Open GastroenterologyVol. 12(1)
University College London Hospitals NHS Foundation Trust (GB), Imperial College Healthcare NHS Trust (GB), The University of Melbourne (AU), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Barts Health NHS Trust (GB), Leeds Teaching Hospitals NHS Trust (GB), Chelsea and Westminster Hospital NHS Foundation Trust (GB), County Durham and Darlington NHS Foundation Trust (GB), Western General Hospital (GB), St George’s University Hospitals NHS Foundation Trust (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Cambridge University Hospitals NHS Foundation Trust (GB), Edinburgh Cancer Research (GB), Calderdale and Huddersfield NHS Foundation Trust (GB), Northern Health and Social Care Trust (GB), Faculty (United Kingdom) (GB), Sheffield Teaching Hospitals NHS Foundation Trust (GB), King's College Hospital NHS Foundation Trust (GB), University Hospitals Sussex NHS Foundation Trust (GB), The Royal Wolverhampton NHS Trust (GB), Wolverhampton Hospital (GB), Mid Yorkshire Hospitals NHS Trust (GB), St Mark's Hospital (GB), University College London (GB), Newcastle University (GB), Teesside University (GB)
Openalex Percentile: Top 70%
Inflammatory Bowel Disease
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