Global, regional and national burden of colon and rectum cancer: a systematic analysis of prevalence, incidence, deaths and DALYs from 1990 to 2021 using data from the Global Burden of Disease Study 2021 with projections to 2036

The burden of colon and rectum cancer has markedly escalated worldwide in the last 30 years. Essential methods to mitigate this trend encompass the reduction of modifiable risk factors, enhancement of early identification and treatment, and augmentation of early screening, particularly for high-risk male populations under 50 years of age. The rising incidence rate among youth underscores the necessity to enhance comprehension of developing risk factors and mechanisms, as well as to advance research on disease prevention and control techniques.