Paeoniflorin Attenuates Cognitive Dysfunction and Neuroinflammation by Autophagy in Mice with SLE Induced by Imiquimod
Paeoniflorin plays a critical neuroprotective role as demonstrated in the TLR-7 agonist imiquimod-induced murine lupus model, mediated through activation of autophagic flux via modulation of the PI3K/AKT/mTOR signaling axis.
Authors
- Teng Ma (ORCID: https://orcid.org/0000-0002-8360-1543)
- Changhao Xie (ORCID: https://orcid.org/0000-0001-5039-5969)
- Yinjiu Huang
- Zhiheng Fan (ORCID: https://orcid.org/0009-0001-4931-8234)
- Baiqing Li (ORCID: https://orcid.org/0000-0001-8351-8267)
- Qian Wang (ORCID: https://orcid.org/0000-0002-2149-384X)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-4190-6418)
- Liping Zhang (ORCID: https://orcid.org/0000-0002-7490-231X)
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0002-3016-5020)
- Peipei Song (ORCID: https://orcid.org/0000-0001-8075-4379)
- Chen Xuan (ORCID: https://orcid.org/0000-0001-6657-7855)
- Yanxin Wang (ORCID: https://orcid.org/0000-0002-2865-9486)
- Xiang Lu (ORCID: https://orcid.org/0000-0003-0647-9123)
- Xi Jin (ORCID: https://orcid.org/0000-0003-0741-8736)
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s524710
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84