<i>Musa balbisiana</i> Colla, an Ethnomedicinal Plant use as Abortifacient among Karbi Tribe of Assam, North East India: An <i>In Silico</i> Characterization

Background: Musa balbisiana Colla is an important ethnomedicinal plant known among the Karbi tribe of Assam for managing unintended pregnancy. Aim: The present study highlighted the physicochemical properties and bioactive compounds present in the medicinal extract along with its ADME properties that predicts the potential compounds as having drug-likeness properties. Methods: Physicochemical analysis was done by simple determination techniques; qualitative and quantitative test for the presence of bioactive compounds in methanol extract were done following standard procedure. Functional groups and potential bioactive compound were characterized by FTIRand GC-MS analysis. The physicochemical, lipophilicity and drug-likeness properties of the compounds, identified from the extract were studied using an online server for ADME. Results: Analysis of physicochemical properties (pH, LOD, extractive value, flowability properties) reveals the nature and quality of the powders drugs. Bioactive compounds like flavonoid, tannins, phenolic content, saponin, alkaloid and steroid were present; the plant have good amount of total flavonoid contents (162.733 mg QE/g), phenolic content with 396.33 mg GAE/g and total alkaloid content as 44 mg/g. Bioactive compounds like 1,2-Benzenedicarboxylic acid, Butyl octyl ester; Dibutyl phthalates;1,2-Benzenedicarboxylic acid, Dipropyl ester; Phthalic acid, Decyl isobutyl ester etc. were reported to show reproductive toxicity. In silico SwissADME analyses revealed the identified compounds follows Lipinski’s rule and shows drugs like characteristics with good bioavailability score. The bioavailability radar revealed the compounds to have drug-like property. Conclusions: Here from the study, we can conclude that rhizomes of M. balbisiana are potential source of phytomedicines. The presence of important bioactive compounds with its ADME properties and bioavailability radar can predict a compound as having drug-likeness and may consider as pharmaceutically important plant based oral drugs in the near future. Major Findings: Rhizome of M. balbisiana Colla is enriched with potential bioactive compounds with efficient abortifacient activities. The identified compounds, as per SwissADME parameters suggest the compounds as having drug-like property and may be considered as pharmaceutically important plant based drugs (orally active) in the near future.