Identification of Key Biomarkers and Immune Microenvironment Features in Ulcerative Colitis: An Integrated Analysis Using WGCNA and Multiple Machine Learning Algorithms
This study identified ten hub genes with potential as biomarkers for the diagnosis and treatment of UC. NCF2 may contribute to UC pathogenesis by modulating inflammatory and immune responses, serving as a potential immune-related biomarker for improved UC diagnosis and treatment.
Authors
- Meijia Cheng
- Wen Li (ORCID: https://orcid.org/0000-0002-5543-4899)
- Yonggang Pei (ORCID: https://orcid.org/0000-0001-7296-8772)
- Siyao Zhang
- Y-F. Qi
- Xinxin Pan
- Yongduo Yu (ORCID: https://orcid.org/0000-0002-2556-983X)
- Wenjing Ma (ORCID: https://orcid.org/0009-0001-8457-5412)
- Yunen Liu (ORCID: https://orcid.org/0000-0001-8761-2402)
- Jiajia Li (ORCID: https://orcid.org/0009-0005-7848-0897)
- Yichen Wang (ORCID: https://orcid.org/0009-0003-9211-0919)
Institutions
- Shenyang Medical College (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Shenyang Anorectal Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s545790
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82