Sequence Diversity Lost in Early Pregnancy
(Abstracted from Nature 2025;642(8068):672–681) Mutations in germ cells are passed from parent to child and occur before fertilization; variations can be evaluated using somatic tissue samples, and germline mutations that appear de novo in offspring (DNMs) have been studied extensively. Many DNMs are paternal, but some have nearly equal maternal and paternal contribution.
Authors
- Gísli H. Halldórsson (ORCID: https://orcid.org/0000-0001-7067-9862)
- Gunnar Pálsson (ORCID: https://orcid.org/0000-0002-8231-3961)
- Bjarni V. Halldórsson (ORCID: https://orcid.org/0000-0003-0756-0767)
- Sigurgeir Ólafsson (ORCID: https://orcid.org/0000-0003-1711-2757)
- Hreinn Stefánsson (ORCID: https://orcid.org/0000-0002-9331-6666)
- Sofie Bliddal (ORCID: https://orcid.org/0000-0002-2456-1019)
- Lilja Stefánsdóttir (ORCID: https://orcid.org/0009-0001-2407-2661)
- Andrew C. Chan (ORCID: https://orcid.org/0000-0001-7523-6139)
- David Westergaard (ORCID: https://orcid.org/0000-0003-0128-8432)
- Louise le Roux (ORCID: https://orcid.org/0000-0002-9491-9653)
- Hákon Jónsson (ORCID: https://orcid.org/0000-0001-6197-494X)
- G. Bragi Walters (ORCID: https://orcid.org/0000-0002-5415-6487)
- Kāri Stefánsson (ORCID: https://orcid.org/0000-0003-1676-864X)
- Agnar Helgason (ORCID: https://orcid.org/0000-0002-8545-3767)
- Hannes P. Eggertsson (ORCID: https://orcid.org/0000-0002-1674-9978)
- Pall I. Olason (ORCID: https://orcid.org/0000-0002-3350-3443)
- Tanja Schlaikjær Hartwig (ORCID: https://orcid.org/0000-0003-4220-5947)
- Sigurjón A. Guðjónsson (ORCID: https://orcid.org/0000-0001-9314-7412)
- Peter Möller (ORCID: https://orcid.org/0000-0003-1405-5136)
- Daníel F. Guðbjartsson (ORCID: https://orcid.org/0000-0002-5222-9857)
- Gudmundur L. Norddahl (ORCID: https://orcid.org/0000-0002-5622-7197)
- Mette Nyegaard (ORCID: https://orcid.org/0000-0003-4973-8543)
- Ólafur Þ. Magnússon (ORCID: https://orcid.org/0000-0002-5285-9904)
- Eva R. Hoffmann (ORCID: https://orcid.org/0000-0002-2588-0652)
- Gudny A. Arnadottir (ORCID: https://orcid.org/0000-0001-6571-423X)
- Karina Banasik (ORCID: https://orcid.org/0000-0003-2489-2499)
- Jennifer R. Gruhn (ORCID: https://orcid.org/0000-0002-4093-142X)
- Henriette Svarre Nielsen (ORCID: https://orcid.org/0000-0003-2106-8103)
- Jona Saemundsdottir
- Patrick Sulem (ORCID: https://orcid.org/0000-0001-7123-6123)
- Valgerður Steinthórsdóttir (ORCID: https://orcid.org/0000-0003-1846-6274)
- Rún Friðriksdóttir
- Arnaldur Gylfason (ORCID: https://orcid.org/0000-0001-5912-4962)
- Brynjar Ö. Jensson (ORCID: https://orcid.org/0000-0002-2252-4134)
- Ásmundur Oddsson (ORCID: https://orcid.org/0000-0002-4606-5163)
- Kristjan H. S. Moore (ORCID: https://orcid.org/0000-0002-9579-4362)
- Palle Duun Rohde (ORCID: https://orcid.org/0000-0003-4347-8656)
- Jesper Friis Petersen
- Unnur Thorsteinsdottir
Publication Details
- Journal
- Obstetrical & Gynecological Survey
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1097/ogx.0000000000001454
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00