Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress
SEMA6D exerts a protective effect against OA by attenuating synovial macrophage-mediated inflammatory responses through the inhibition of NLRP3 inflammasome activation and endoplasmic reticulum stress.
Authors
- Yong Huang (ORCID: https://orcid.org/0000-0001-7444-5182)
- Xiaolong Lin (ORCID: https://orcid.org/0000-0001-5414-5879)
- Yaojun Lu
- Jiapei Yao (ORCID: https://orcid.org/0009-0002-5807-1226)
- Xindie Zhou (ORCID: https://orcid.org/0000-0001-6194-6308)
- Wenchao Zhang (ORCID: https://orcid.org/0000-0001-8610-8802)
- Zhonghua Xu (ORCID: https://orcid.org/0000-0003-0254-563X)
- C. Li (ORCID: https://orcid.org/0000-0003-1797-9887)
- Zili Guo
Institutions
- Jiangsu University (CN)
- Zhejiang Cancer Hospital (CN)
- Jingchu University of Technology (CN)
- Qinghai Tibetan Hospital (CN)
- Jintan People's Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Southwest Jiaotong University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s525953
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00