Immune System‐Related Genetic Risk Factors for Inhibitory Antibody Development in Patients With Hemophilia: Reviewing an Old Problem From a New Perspective—A Narrative Review
The presence of inhibitory antibodies in patients with severe hemophilia may be associated with immune system-related genetic risk factors, and several studies have shown that in most cases, immune system-related polymorphisms (rs2476601 PTPN22, rs2069812 IL5, and rs1800629 TNF-α) produce autoimmune antibodies or exacerbate them.
Authors
- Najmaldin Saki (ORCID: https://orcid.org/0000-0001-8494-5594)
- Fatemeh Zeylabi (ORCID: https://orcid.org/0000-0002-8765-2516)
- Mojtaba Aghaei (ORCID: https://orcid.org/0000-0002-6382-6657)
Institutions
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Shahrekord University of Medical Sciences (IR)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/hsr2.71331
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ahvaz Jundishapur University of Medical Sciences