USE AND MISUSE OF ANTIBIOTICS IN DIFFERENT MEDICAL DEPARTMENTS IN MISURATA CENTRAL HOSPITAL

The pattern of antibiotics use in hospital settings has been linked to the rising threat of antibiotic resistance. Thereare established global efforts to encourage reporting of antibiotic consumption in hospital settings. Unfortunately,those studies of antibiotic consumption levels on our national level are limited. So the aim of this study was to tracklevels of antibiotic consumption in different medical departments in Misurata Central Hospital during December2016 in order to identify and report any potential evidence of antibiotics misuse. A retrospective cross sectionalstudy was conducted in 2017 using data from patient files who were admitted to Misurata Central Hospital in December 2016 in 12 different departments. 1001 patient`s files were reviewed and data was analyzed. The antibioticuse rate expressed as days of therapy per 1000 patient days (DOT/1000PD). The patients were categorized into twogroups; group with risk factors for Multi-Drug Resistant bacteria "MDR"305 (30.46%) and the other has no riskfactor (69.54%). More than half of the admitted patients received antibiotics during their hospital stay, 649(64.84%), and about two third of the risky group patients received antibiotics, 181 (59.34%). Culture and Sensitivitywas only ordered for 11 patients (6.07%). The rate of antibiotic use expressed as days of therapy per 1000 patientdays (DOT/1000PD) was 1,487. Most of the admitted patients received antibiotics, and most of them had no Cultureand Sensitivity orders. The overall usage of antibiotics exceeds the mean of 855 DOT/1000PD reported in a studyfrom USA capturing aggregate data using electronic claim from different wards. We recommend the implementationof Antibiotics Stewardship Programs “ASP” inside the hospital to establish a policy of antibiotic prescription to different kind of patients in order to decrease the antibiotic misuse and to prevent the development of antibiotic resistance.