POSSIBLE EFFECT OF ATORVASTATIN IN PREVENTING HEMORRHAGIC CYSTITIS INDUCED BY CYCLOPHOSPHAMIDE IN RATS

Cyclophosphamide (CP) is an antineoplastic agent used for the treatment of many neoplastic and inflammatory diseases. Hemorrhagic cystitis is a frequent side effect of CP. Several studies show’s that atorvastatin has importantpleiotropic (anti-inflammatory and immunomodulatory) effects. The purpose of the study was to investigate the effect of atorvastatin in prevention from HC induced by CP. Thirty rats were divided into 5 main groups: Control, CP,CP and MESNA, CP and Atorvastatin, CP- MESNA and Atorvastatin. The bladder was collected and histopathological evaluated. Atorvastatin Show’s significant reduction in HC scoring, MESNA still superior than Atorvastatin inprevention of HC, combination both Ator And MESNA show’s no additive effect.