Potentials of Intranasal Administration of Paracetamol

INTRODUCTION: Currently, there is an urgent issue of safe and minimally invasive administration of medical drugs ensuring rapid and selective delivery of them to the target organs. This review considers the experience of intranasal administration of drugs from different groups, such as NSAID, hormonal agents and anticonvulsants. AIM: Based on the analysis of the scientific medical literature, to describe the current data concerning the use of medical drugs with intranasal administration and consider the possibility of intranasal use of paracetamol. An analysis of publications found in eLibrary, Scopus, PubMed databases using Google Scholar and Web of Science search engines have been conducted. In total, more than 100 sources have been examined with most significant ones included in the reference list. CONCLUSION: Of interest for us is the possibility of intranasal route of administration of paracetamol in view of its widespread use in different groups of patients. Intranasal administration eliminates the phenomenon of the primary passage of the drug through the liver, thus achieving its higher serum concentrations. Currently, most researchers tend to explain the mechanism of paracetamol action through realization of central effects. Paracetamol metabolism in the liver, involving cytochrome system isoenzymes, produces toxic metabolites conditioning the main adverse reactions of the drug, which limits its use in patients with impaired function of excretory organs.The development of a pharmaceutical form for intranasal administration of paracetamol may provide an opportunity to avoid toxicity and other undesirable effects of the drug and expand the groups of patients indicated for use of this drug, and will probably allow for a reduction in the therapeutic dose when administered.