Histological and Physiological evaluation of Hydroxycut and Refit orlistat hepatotoxicity in male albino rats

Obesity has become common all over the world, threatening people's daily lives and also threatening animal health as well as increasing the risk of obesity-related diseases. Dietary supplements such as Hydroxycut and Refit orlistat targeting obesity have gained popularity and are now a prevalent cause of drug-induced liver impairment and hepatotoxicity. This study aims to assess the effect of Hydroxycut and Revit Orlistat on the liver histologically and physiologically. Male albino rats were employed in the current investigation, which ran from August 29, 2022, until April 29, 2023. Thirty blood samples from albino male rats were used in the investigation. Six groups of five rats each were created from the categorization of the rats. One of the groups served as control group. The results of histological examination of liver of rats showed various changes, ranging from the appearance of desquamation of the central vein wall, hemorrhage, vacuolation of hepatocyte, dilation of sinusoids, Kupffer cells, and necrosis as well. This study quantified the concentrations of AST and ALT in blood serum and demonstrated a noteworthy elevation in both. Furthermore, there were statistically significant disparities at a probability threshold of less than 0.05. The study demonstrated that Hydroxycut and Orlistat exert a direct detrimental impact on liver tissue, leading to the development of acute liver failure. Therefore, it is important to consider the toxicity of these drugs while prescribing them, especially in elderly patients and patients with kidney and liver disease.