TRAF2 and NCK interacting kinase: a novel regulator of integrin αIIbβ3 signaling in platelets
In summary, we confirm TNIK is present in platelets and is important for platelet function, and thrombus formation. For the first time, we show that platelet TNIK is able to associate with key cytoskeletal regulators, linking its signaling to integrin α<sub>IIb</sub>β<sub>3</sub> function. Future studies will focus on exploring a potential role of TNIK in the regulation of thrombosis and hemostasis <i>in vivo</i> to assess TNIK's potential as a novel antithrombotic target.
Authors
- Scott Spencer
- Richa Bedi
- Rebecca Lewis (ORCID: https://orcid.org/0000-0003-1395-3276)
- Lisa‐Marie Holbrook (ORCID: https://orcid.org/0000-0001-8752-1885)
- Lily J. Bull
Institutions
- University of Surrey (GB)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.103204
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00