Neutrophil extracellular traps-targeting therapy with deoxyribonuclease 1 reduces large vessel occlusion-induced downstream microvascular thromboinflammation in a rat model of stroke
Our results confirm that NETs contribute to DMT during AIS and that early NET-targeting therapy may represent a new strategy to improve the clinical benefit of large vessel recanalization in AIS.
Authors
- Mialitiana Solo Nomenjanahary
- Lucas Di Meglio (ORCID: https://orcid.org/0000-0002-5158-8612)
- Sébastien Dupont (ORCID: https://orcid.org/0000-0002-3737-3500)
- Véronique Ollivier (ORCID: https://orcid.org/0000-0003-1318-1712)
- Laurine Bedoucha
- Mikaël Mazighi (ORCID: https://orcid.org/0000-0003-0911-8999)
- Martine Jandrot‐Perrus (ORCID: https://orcid.org/0000-0002-8450-9247)
- Clément Journé (ORCID: https://orcid.org/0000-0003-4467-435X)
- Thomas Rambaud (ORCID: https://orcid.org/0000-0003-1677-0838)
- Benoît Ho‐Tin‐Noé
- Jean‐Philippe Desilles
- Fatima Zemali
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Laboratoire d’Imagerie Biomédicale (FR)
- Hôpital Lariboisière (FR)
- Fondation de Rothschild (FR)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
- FHU Neurovasc (FR)
- Imagerie par Résonance Magnétique Médicale et Multi-Modalités (FR)
- French Clinical Research Infrastructure Network (FR)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.103206
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00