The influence of social and non-social factors on destabilization and reconsolidation of negative memory

The current paper reviews the literature on the influence of social and non-social factors on the destabilization and reconsolidation of negative memory. The non-social influences: neuropharmacological (beta-adrenergic receptor antagonists, glutamatergic NMDA receptor antagonists and GABAergic receptor agonists) and behavioral interventions are described. The latter are associated with the inclusion in the process of reactivation of aversive memory, extinction, a new environment, stress, positive information, etc. The molecular-cellular mechanisms associated with the processes of destabilization and reconsolidation of memory, describing a behavioral tagging and the role of reinforcement prediction errors in these processes is also considered. The influence of social factors on memory reactivation/reconsolidation is shown. The mechanisms of transmission of the conditioned fear reaction, mitigation (fear buffering) and generalization of negative memory under the influence of a social partner are described. And finally, depending on the different nature of social interaction between learned animals, the degree of their freezing (fear) in the phase of reactivation and generalization of memory is given, with consideration of possible structural and functional mechanisms (using methods of optogenetics and early gene expression) of the observed behavioral changes.