Sirtuins and their role in the regulation of multipotent mesenchymal stromal cells metabolism

Sirtuins are proteins of the histone deacetylase family involved in the epigenetic regulation of various cellular functions. In this review, the functions of sirtuins in multipotent mesenchymal stromal cells (MMSCs) were analyzed based on available literature data. These proteins play a very important role in energy metabolism, differentiation, and aging of MMSCs. Their role in defense against oxidative stress has been shown. The participation of sirtuins in MMSCs-specific gene regulation is described.