MITOCHONDRIA OF ENDOCRINE CELLS OF INTESTINE MUCOSA EPITHELIUM IN A MELATONIN-TREATED RATS (ELECTRONIC MORPHOMETRIC STUDY)

The ultrastructure of mitochondria of endocrinocytes of the epithelium of the mucous membrane of the duodenum and colon of rats was studied in 2 subgroups of the experiment: with the introduction of 1 and 100 therapeutic doses of melatonin solution. When melatonin was administered in the studied parts of the intestine, it was revealed: a change in the content of 95-90 % endocrine cells in the cytoplasm of the studied organelles, their swelling (85 % of organelles), fragmentation of crystals (70 % of organelles), enlightenment of their matrix (5 % of organelles) and the appearance of myelin-like structures (1-2 % of organelles) were revealed. The detected structural changes may indicate an increase in the metabolic activity of epithelial endocrinocytes in response to experimental exposure, which requires regenerative correction of mitochondrial dynamics.