Colloidal Interactions in Simulated Intestinal Fluids: Implications for Oral Drug Delivery at the Nanoscale
Oral Drug Delivery Nanoparticles in action! In article number 2500350, Juliane Fjelrad Christfort, Matteo Tollemeto, and co-workers illustrate how bile salts and lipids in simulated intestinal fluids shape particle behavior. These components govern properties from aggregation to mucoadhesion and cytotoxicity, revealing the underlying mechanisms that control nanoparticle performance in the gut and affect drug delivery effectiveness.
Authors
- Jan C. M. van Hest (ORCID: https://orcid.org/0000-0001-7973-2404)
- Matteo Tollemeto (ORCID: https://orcid.org/0000-0002-6220-2877)
- Lasse Højlund Eklund Thamdrup (ORCID: https://orcid.org/0000-0002-9498-1529)
- Juliane Fjelrad Christfort (ORCID: https://orcid.org/0000-0002-8378-1804)
- Anja Boisen (ORCID: https://orcid.org/0000-0002-9918-6567)
- Yudong Li (ORCID: https://orcid.org/0009-0006-9140-5733)
Institutions
- Danish National Research Foundation (DK)
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- Small Science
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/smsc.70106
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00