EFFECT OF THE DRUG PROAUTOVAC ON THE IMMUNE STATUS AND THE LEVEL OF IL-2 GENE EXPRESSION IN CALVES WITH COMORBID PATHOLOGIES

The article describes the results of a study on the assessment of the level of IL-2 gene expression in healthy calves and in calves with comorbid pathologies due to hypotrophy and immunodeficiency, as well as after pharmacocorrection with cytokine-based drugs. The experiment was conducted on newborn calves divided into 3 groups: healthy animals served as controls, the Proautovac group – sick calves treated with a drug based on species-specific cytokines Proautovac, the Mixoferon group – sick calves treated with a drug based on a non-species-specific cytokine Mixoferon. During the experiment, it was found that in sick calves of the Proautovac group, after pharmacocorrection with a drug based on the species-specific cytokine Proautovac, an earlier process of mobilization of the body's defenses occurs, as indicated by an increase in the expression level of the proinflammatory IL-2 gene on the 17th day relative to other groups. It is also worth noting that the use of Proautovac also activated the processes of reducing gene expression on the 24th day, which indicates a fastercompletion of the course of inflammatory processes.