Possibilities of Microbiological Monitoring in a Surgical Hospital and Perinatal Center: Local Experience

INTRODUCTION: Antibiotic resistance (non-susceptibility or resistance of infectious disease agents to antibiotics) has been and remains one of important problems of modern medicine. It reduces the effectiveness of treatment, leads to increase in morbidity and mortality, and, in some cases, to persistent bacterial carriage. Local monitoring of antibiotic resistance is a tool to overcome it. AIM: To study and describe the local monitoring data of antibiotic resistance of strains of microorganisms isolated from various patients’ loci of two hospitals: surgical departments of City Clinical Hospital No. 24 of Moscow Health Department (MHD) and Perinatal Center of Bauman City Clinical Hospital No. 29 of MHD. To show the prevailing organisms, analyze their susceptibility, assess the possibilities of conducted therapy. MATERIALS AND METHODS: A large number of loci were studied in cultures, microorganisms were isolated using MALDI-TOF mass spectrometry, antibiotic resistance was determined using the disk diffusion method for assessing susceptibility. RESULTS: In the perinatal center of Bauman City Clinical Hospital No. 29, the most frequently occurring microorganism is Enterococcus faecalis (26.70%), coagulase-negative staphylococci rank second (18.20%), and Candida fungi (14.30%) and Escherichia coli (12.50%) rank third. In the coloproctology center of City Clinical Hospital No. 24 of MHD, the most prevalent microorganism is Escherichia coli (33.94%) (with sensitivity to cephalosporins 53.48%, to aminoglycosides 74.50%, to carbapenems 75.90%). Twenty seven point twelve percent of Escherichia coli strains are resistant to fluoroquinolones, 20.78% to protected aminopenicillins, and 1.39% to colistin. Microorganisms from the ESKAPEE group are present in hospitals in different quantities, the most common being Klebsiella pneumoniae (16.69% of all strains), Staphylococcus aureus (6.58%), and Acinetobacter baumannii (4.65% of all strains). CONCLUSION: The antibacterial treatment policy in hospitals is adequate, but ESKAPEE group pathogens remain a problem.