Evaluation of the Effectiveness of Prevention of Thrombotic Complications in Comorbid Patients after Surgical Interventions

INTRODUCTION: Prevention of thrombotic complications in patients subjected to surgical interventions remains an important problem in the healthcare system. Particularly challenging is a large group of comorbid patients for whom the scope and duration of preventive measures have not yet been determined. AIM: To evaluate the effectiveness of preventive programs directed at reducing the risk of thrombotic complications in patients with gastric ulcers diseases. MATERIALS AND METHODS: The study is a retrospective analysis of the treatment results of 120 high-risk patients with gastric ulcers diseases having a large number of comorbid diseases. Surgical intervention of the main disease was performed via laparoscopic access; the amount of phlebological manipulations was determined by the study group. The data were analyzed using MS Excel 19 spreadsheets and Statistical 10 statistical package. The Pearson χ2 criterion and Fishers exact test were used as methods for assessing the relationship between qualitative parameters for unrelated groups; Kruskal–Wallis test for three groups and the Mann–Whitney test for two groups were used to analyze quantitative parameters. RESULTS: Statistically significant results were determined for the total number of complications, which was 10 cases (25.0%) in group 1 and 3 cases (7.7%) in group 3, p=0.038. No differences were found in the analysis of the frequency of hemorrhagic complications between all groups, as well as between individual pairs during subsequent analysis. The analysis of the results of the laboratory tests of patients in all study groups after the main stage of treatment revealed statistically significant differences only in the parameters of hyperthrombinemia, in particular, D-dimer, fibrinogen. CONCLUSION: Prevention of thrombotic complications, including crossectomy and endovenous coagulation, as well as drug therapy, helps reduce the risk of their development in comorbid patients with gastric ulcers diseases.