Role of osteoporosis and diabetes on facial and long bone fracture healing under various loading conditions
The independent and combined effects of osteoporosis and diabetes on mandibular and tibial fracture healing under varied mechanical loading in a rat model (n=120) is of interest. Osteoporosis and diabetes each impaired healing, with comorbid rats showing the most severe reductions in BMD (Bone Mineral Density) and biomechanical strength. Cyclic loading worsened outcomes in diabetic rats, while reduced loading benefited osteoporotic fractures. Disarranged angiogenesis and collagen organization in comorbid groups is confirmed histologically. Thus, we show the need to customize various procedures in patients with systemic comorbidities.
Authors
- Jugajyoti Pathi (ORCID: https://orcid.org/0009-0005-8906-0097)
- Pradeep Pattar
- Neha Jain (ORCID: https://orcid.org/0000-0003-3827-5598)
- Aaquib Nazir
- Preeti Dhir
- Miral Mehta
- Veeranan Yadav P
- Ishaan Saha
Institutions
- Sant Gadge Baba Amravati University (IN)
- Sri Ramachandra Institute of Higher Education and Research (IN)
- Government Royapettah Hospital (IN)
- Baba Farid University of Health Sciences (IN)
- Oxford Dental College and Hospital (IN)
- College of Medicine & JNM Hospital (IN)
- People’s University (IN)
- Karnavati University
- KIIT University (IN)
Publication Details
- Journal
- Bioinformation
- Published
- 2025-09-30
- DOI
- https://doi.org/10.6026/973206300213305
- Primary Topic
- Facial Trauma and Fracture Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00