[89Zr]Zr-DFO-avelumab accumulation in resectable non-small cell lung carcinoma indicates a suppressive tumor microenvironment amendable to neoadjuvant avelumab treatment

[<sup>89</sup>Zr]Zr-DFO-avelumab PET imaging is a safe and feasible approach in early-stage NSCLC. Higher [<sup>89</sup>Zr]Zr-DFO-avelumab tumor-accumulation at baseline strongly correlates with features of a suppressive tumor immune environment and response to neoadjuvant avelumab.

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Publication Details

Journal
Immunotherapy Advances
Published
2024-12-30
DOI
https://doi.org/10.1093/immadv/ltaf030
Primary Topic
Radiopharmaceutical Chemistry and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

[89Zr]Zr-DFO-avelumab accumulation in resectable non-small cell lung carcinoma indicates a suppressive tumor microenvironment amendable to neoadjuvant avelumab treatment

Francesco Ciompi, Iris A.E. van der Hoorn, Guus R. M. van den Heuvel, Ad F. T. M. Verhagen et al.
Immunotherapy Advances
Radiopharmaceutical Chemistry and Applications
article

[89Zr]Zr-DFO-avelumab accumulation in resectable non-small cell lung carcinoma indicates a suppressive tumor microenvironment amendable to neoadjuvant avelumab treatment

Francesco Ciompi, Iris A.E. van der Hoorn, Guus R. M. van den Heuvel, Ad F. T. M. Verhagen, Shoko Vos, Carla M.L. van Herpen, Erik H.J.G. Aarntzen, Lieke L. van der Woude, Sandra Heskamp, I. Jolanda M. de Vries, Michel M. van den Heuvel, Berber Piet, Evelien A. J. van Genugten, Sarah R. Verhoeff
article en

Abstract

[<sup>89</sup>Zr]Zr-DFO-avelumab PET imaging is a safe and feasible approach in early-stage NSCLC. Higher [<sup>89</sup>Zr]Zr-DFO-avelumab tumor-accumulation at baseline strongly correlates with features of a suppressive tumor immune environment and response to neoadjuvant avelumab.

Immunotherapy AdvancesVol. 5(1)
University Medical Center Groningen (NL), Radboud University Nijmegen (NL), University Medical Center (US), Radboud University Medical Center (NL), University Medical Center Utrecht (NL), University Hospital and Clinics (US), Radboud Institute for Molecular Life Sciences (NL), Zuyderland Medisch Centrum (NL)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Radboud Institute for Health Sciences
Openalex Percentile: Top 55%
Radiopharmaceutical Chemistry and Applications
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