[89Zr]Zr-DFO-avelumab accumulation in resectable non-small cell lung carcinoma indicates a suppressive tumor microenvironment amendable to neoadjuvant avelumab treatment
[<sup>89</sup>Zr]Zr-DFO-avelumab PET imaging is a safe and feasible approach in early-stage NSCLC. Higher [<sup>89</sup>Zr]Zr-DFO-avelumab tumor-accumulation at baseline strongly correlates with features of a suppressive tumor immune environment and response to neoadjuvant avelumab.
Authors
- Francesco Ciompi
- Iris A.E. van der Hoorn (ORCID: https://orcid.org/0009-0008-8644-0678)
- Guus R. M. van den Heuvel (ORCID: https://orcid.org/0000-0002-5000-3213)
- Ad F. T. M. Verhagen (ORCID: https://orcid.org/0000-0003-0852-9681)
- Shoko Vos (ORCID: https://orcid.org/0000-0001-7807-3056)
- Carla M.L. van Herpen (ORCID: https://orcid.org/0000-0001-5130-5451)
- Erik H.J.G. Aarntzen (ORCID: https://orcid.org/0000-0002-3809-0182)
- Lieke L. van der Woude (ORCID: https://orcid.org/0000-0002-4761-0768)
- Sandra Heskamp (ORCID: https://orcid.org/0000-0001-7250-0846)
- I. Jolanda M. de Vries (ORCID: https://orcid.org/0000-0002-8653-4040)
- Michel M. van den Heuvel (ORCID: https://orcid.org/0000-0002-6372-2153)
- Berber Piet (ORCID: https://orcid.org/0000-0002-9069-3597)
- Evelien A. J. van Genugten (ORCID: https://orcid.org/0000-0002-7589-4294)
- Sarah R. Verhoeff (ORCID: https://orcid.org/0000-0003-4679-8938)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- University Hospital and Clinics (US)
- Radboud Institute for Molecular Life Sciences (NL)
- Zuyderland Medisch Centrum (NL)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/immadv/ltaf030
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Radboud Institute for Health Sciences