Prevalence and clinical impact of JAK2-CHIP: Association with Parkinsonism and hematologic changes in a population cohort
JAK2-CHIP is associated with increased prevalence of Parkinsonism in otherwise healthy individuals, possibly via microvascular or inflammatory pathways. Elevated platelet and basophil counts among carriers support early functional consequences of this mutation. These findings highlight the clinical relevance of detecting JAK2-CHIP in general populations and underscore its potential as a biomarker for neurologic risk stratification and longitudinal monitoring.
Authors
- Ying‐Hsuan Wang (ORCID: https://orcid.org/0000-0003-4764-7592)
- Meng‐Hung Lin (ORCID: https://orcid.org/0000-0002-8594-3360)
- Yi-Yang Chen (ORCID: https://orcid.org/0000-0002-7675-0129)
- Yao-Ren Yang
- Cih‐En Huang (ORCID: https://orcid.org/0000-0001-5921-5346)
- Yuying Wu (ORCID: https://orcid.org/0009-0006-0341-2707)
- Hsing-Yi Tsou
- Chian-Pei Li
- Wei‐Lun Tsai (ORCID: https://orcid.org/0000-0001-7557-3370)
- Chih‐Cheng Chen (ORCID: https://orcid.org/0000-0002-6794-7229)
- Chia‐Hung Wu (ORCID: https://orcid.org/0000-0003-4489-3050)
- Chang-Hsien Lu
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- Taipei Veterans General Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Journal of the Formosan Medical Association
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jfma.2025.09.039
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00