System mechanisms of urine formation and transport. Message 1. Features of the storage-evacuation function of the bladder in young people with different urination rhythms

The relevance of the study is determined by the high prevalence of symptoms of the lower urinary tract, as well as the search for new intersystem relationships in the implementation of the accumulative evacuation function of the bladder using modern diagnostic methods and highlighting criteria for early diagnosis of these disorders. Based on the results of current preventive examinations, including the recommendations of the American Continence Society (ISC), urination diaries were filled out for 3 days, a survey of lower urinary tract symptoms on the I-PSS scale, and quality of life assessments (QOL). Three groups of young males had been divided – with normal (183 people, average age 27.3 ± ± 1.5 years), borderline (52 people, average age 26.8 ± 1.7 years) and increased urination rhythm (total 53 people, average age 28.1 ± 1.8 years). Additionally, the individual volume of habitual physical activity – HPA (mobile application on the Android and Apple platforms) was assessed. Combined positron emission and computed tomography (PET/CT) with a total mathematical calculation of the standardized capture level of Maximum Standardized Uptake Value (SUVmax), the maximum indicator of the degree of accumulation of radiopharmaceuticals in the selected area of interest by various brain zones 18F-FDG, 11C-methionine and 11C-choline was performed in different functional phases of work bladder (filling, urination and after emptying) on a Biograph machine (Siemens, Germany). As a result of the studies, quantitative and qualitative characteristics were given to the energy metabolism of the brain in the process of implementing the storage and evacuation functions of the bladder in young people with normal, borderline and frequent urination rhythms. The consistent functional activity of the most significant sections (anterior and posterior cingulate cortex, paracentral lobule, thalamus, insula) in different phases of urination has been established, and on this basis a standard model of the central regulation of the storage-evacuation function of the bladder has been proposed.