p-toluenesulfonic acid monohydrate concentration effect on the cyclohexene methoxycarbonylation reaction

Taking into account the data on water binding to stable acetic acid hydrates, an interpretation of the dependence of the rate of the cyclohexene methoxycarbonylation reaction catalyzed by the system Pd(OAc)2 – PPh3 – p-toluenesulfonic acid monohydrate, depending on the last component concentration is proposed. This reaction mechanism scheme is supplemented by the reaction of formation of stable acetic acid hydrates AcOH×(H2O)n, where n =1–10. The effective rate constant of cyclohexene methoxycarbonylation has been estimated. It is con-cluded that the stable acetic acid hydrates formation in the presence of small water amounts in toluene medium is possible.