Self‐Reinforced MOF‐Based Nanogel Alleviates Osteoarthritis by Long‐Acting Drug Release (Adv. Mater. 39/2024)
Self-Reinforced MOF-Based Nanogel In article number 2401094, Mingzhu Zhang, Huiyu Liu, Qi Gu, and co-workers report a long-acting nanogel as a drug carrier based on MOFs, KZIF@HA. This nanogel responds to the inflammatory microenvironment of osteoarthritis, enabling the sustained release of kartogenin and Zn2+ over an extended period. Moreover, KZIF@HA significantly enhances the synthesis of extracellular matrix and the polarization of M2 macrophages. It also inhibits JNK and ERK signaling pathways, thereby achieving a multifaceted regulation of the pathological environment associated with osteoarthritis.
Authors
- Bingyin Jiang (ORCID: https://orcid.org/0000-0002-9526-5727)
- Xiyuan Zhao (ORCID: https://orcid.org/0000-0001-9131-6243)
- Qi Gu (ORCID: https://orcid.org/0000-0001-9387-9525)
- Shenglong Ding (ORCID: https://orcid.org/0000-0003-0682-3596)
- Mingzhu Zhang (ORCID: https://orcid.org/0000-0002-6975-4965)
- Min Chen (ORCID: https://orcid.org/0000-0002-2334-8320)
- Chunlin Zhu
- Yun Sun
- Yu-Han Yang
- Huiyu Liu (ORCID: https://orcid.org/0000-0003-4465-8501)
- Dadi Sun
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Institute of Zoology (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/adma.202470310
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.41