Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression (Adv. Sci. 37/2025)
Gamma-Glutamyl Cysteine liGaseGLed is a reversible europium-based sensor for glutathione that allows real-time, single-cell tracking of Gamma-Glutamyl Cysteine Ligase (GCL) activity, a function still not fully understood in human T cells.GLed directly links GCL activity to T cell effector functions, revealing that GCL is a critical regulator and a potential therapeutic target for immune-related diseases.
Authors
- Rafael Salto (ORCID: https://orcid.org/0000-0002-7044-3611)
- Juan A. González‐Vera (ORCID: https://orcid.org/0000-0002-8199-1330)
- Miguel Fribourg (ORCID: https://orcid.org/0000-0003-1804-8136)
- Laura Espinar‐Barranco (ORCID: https://orcid.org/0000-0001-5371-8671)
- Mehek Ningoo (ORCID: https://orcid.org/0000-0001-8318-3508)
- Carmen Salto‐Giron
- Rosario Herranz (ORCID: https://orcid.org/0000-0002-0273-2761)
- José M. Paredes (ORCID: https://orcid.org/0000-0002-3252-9174)
- Ángel Orte (ORCID: https://orcid.org/0000-0003-1905-4183)
- Francisco Fueyo‐González (ORCID: https://orcid.org/0000-0001-6837-3928)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/advs.71805
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00