Restoring TB-specific Immunity in Early HIV Infection—the Dual Promise of Early Antiretroviral and TB Preventive Treatment
Abstract Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tuberculosis preventive treatment indispensable—potentially lifelong—to close immunologic gaps and reduce HIV-associated TB morbidity and mortality.
Authors
- Jerry W. Simecka (ORCID: https://orcid.org/0000-0001-8262-3823)
- Patrick K. Moonan (ORCID: https://orcid.org/0000-0002-3550-2065)
- Stephen O. Mathew (ORCID: https://orcid.org/0000-0001-5784-224X)
- Stephen E. Weis
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1093/infdis/jiaf518
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00