Alpha-internexin as a brain-specific neurodegeneration marker: development and validation of a novel CSF assay
We developed a highly sensitive and specific immunoassay for AINX in CSF. AINX showed similar diagnostic performance and high correlation with CSF NfL. Further research should focus on describing its role in specific disorders, as well as evaluate its potential as a blood-based biomarker.
Authors
- Gunnar Brinkmalm (ORCID: https://orcid.org/0000-0001-6958-2393)
- Edward J. Wild (ORCID: https://orcid.org/0000-0002-6921-7887)
- Claire A. Leckey (ORCID: https://orcid.org/0000-0001-5268-3681)
- Hlin Kvartsberg (ORCID: https://orcid.org/0000-0002-4481-508X)
- Ulf Andréasson (ORCID: https://orcid.org/0000-0001-8622-052X)
- Francisco J. Meda (ORCID: https://orcid.org/0000-0002-3343-7351)
- Anna Dittrich (ORCID: https://orcid.org/0000-0002-5168-2975)
- Ross W. Paterson (ORCID: https://orcid.org/0000-0001-9372-3635)
- Silke Kern
- Ingmar Skoog
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Huntington's Disease Association (GB)
- Institute for Neurodegenerative Disorders (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Indian Institute of Science Bangalore (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1007/s00415-025-13428-y
- Citations
- 2
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- CHDI Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Huntington's Disease Network
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Stiftelsen Psykiatriska Forskningsfonden
- Alzheimerfonden
- UK Dementia Research Institute
- Fondation pour la Recherche sur Alzheimer
- HORIZON EUROPE Framework Programme