130324 Prevalence of peripapillary hyperreflective ovoid mass-like structures in children: a systematic review and meta-analysis

2024, were included (n = 464).ROP screening was performed in accordance with national guidelines.A detailed subset of 73 infants with complete ophthalmologic records was analysed for disease severity, treatment modalities, and associated clinical factors.Of the total cohort, 50 infants (10.7%) required treatment for ROP.Among the 73 infants in the detailed cohort, 68.4% were inborn and 31.5% were transferred from other hospitals.Advanced ROP (Stage 3) was observed in 75.3% of treated infants.The mean gestational age at birth was 24 weeks.Notably, 61.6% received a complete antenatal steroid course, while 56.1% required postnatal steroids.The mean durations for parenteral nutrition, invasive ventilation, and total ventilation (invasive + non-invasive) were 45, 54, and 72 days respectively.Surgical necrotizing enterocolitis occurred in 31.5% of cases, and chorioamnionitis was noted in 5.4%.The mean corrected gestational age at Threshold ROP diagnosis was 36 weeks.All ROP cases received treatment: 78% with laser photocoagulation alone, 16.4% with intravitreal Avastin, and 4.1% with Lucentis.One case received combination therapy.Four infants (5.4%) required referral for vitrectomy.The incidence of treatment-requiring ROP was 10.7% over the ten-year period.Most affected infants presented with severe disease.These findings underscore the importance of early screening and timely intervention in high-risk neonatal populations to prevent vision loss.