Identifying Immuno-Fibrotic Roles of Lactylation-Related T Cell Hub Genes in Renal Ischemia–Reperfusion Injury: A Multi-Omics Study and Experimental Validation
This multi-omics study identified a key lactylation-associated hub T cell potentially implicated in post-IRI induced maladaptive repair. Four lactylation-related T-cell biomarkers (CORO1A, HLA-E, IGHM, and TUBA1A) predicted allograft maladaptive repair and survival, providing a precise framework for early risk stratification and potential therapeutic intervention.
Authors
- Xuemeng Qiu (ORCID: https://orcid.org/0000-0003-0862-9164)
- Jiyue Wu (ORCID: https://orcid.org/0000-0001-8715-8756)
- Zejia Sun (ORCID: https://orcid.org/0000-0003-1079-3019)
- Yifei Zhang (ORCID: https://orcid.org/0009-0003-5299-828X)
- Zhen Li (ORCID: https://orcid.org/0000-0002-2520-0354)
- Wei Wang (ORCID: https://orcid.org/0000-0003-2642-3338)
- Hao Wang (ORCID: https://orcid.org/0009-0003-3042-4015)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s548708
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00