ZnPPIX-Loaded Nanoemulsions Reprogram Immunosuppressive Macrophages in Vitro: A Potential Strategy for Glioblastoma Microenvironment Modulation
Our findings suggest that NE-ZnPPIX may represent a novel and effective strategy for remodeling the immunosuppressive TME of GBM in combination with established immune-stimulating therapies. This approach has the potential to enhance the efficacy of immunotherapy by overcoming the tumor immune evasion mechanisms.
Authors
- Giovanna Lollo (ORCID: https://orcid.org/0000-0001-7030-3056)
- Ada Tushe (ORCID: https://orcid.org/0009-0002-0687-7834)
- Sara Zumerle (ORCID: https://orcid.org/0000-0001-6980-0629)
- Susanna Mandruzzato (ORCID: https://orcid.org/0000-0002-0707-995X)
- Camilla Bonaudo (ORCID: https://orcid.org/0000-0002-0888-7377)
- Francesco Volpin (ORCID: https://orcid.org/0000-0002-7337-9192)
- Edmund R. Marinelli
- Alessandro Della Puppa (ORCID: https://orcid.org/0000-0001-8058-092X)
- Annavera Ventura (ORCID: https://orcid.org/0000-0001-5433-7512)
- Valentina Andretto (ORCID: https://orcid.org/0000-0002-5002-6212)
- Hanäé Guérin
- Olga Slukinova
- Giulia Zampardi
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Padua (IT)
- Institut Universitaire de France (FR)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Laboratoire d'Automatique, de Génie des Procédés et de Génie Pharmaceutique (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Florence (IT)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijn.s533321
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Ministero della Salute
- Università degli Studi di Padova