FAK-Induced Time Dependent Cell Response Profiling: Prediction, Identification, and Analysis of Anti-Tumor Immune Natural Products
Collectively, MCR is identified as a FAK-targeting agent through FAK-TCRPs. MCR inhibits TAMs, CTLA-4, and chemokine transcription via the FAK/MMPs pathway, showing antitumor effects in breast cancer.
Authors
- Jingan Lou (ORCID: https://orcid.org/0000-0001-9142-5378)
- Jianhui Fu (ORCID: https://orcid.org/0000-0002-4321-3685)
- Ningning Bai
- Weiye Mao
- Mengyun Chen
- Qiyang Shou (ORCID: https://orcid.org/0000-0003-1615-5309)
- Xia Liu (ORCID: https://orcid.org/0000-0002-9987-3332)
- Huiying Fu (ORCID: https://orcid.org/0000-0002-1782-5258)
- Jin Lü (ORCID: https://orcid.org/0009-0009-1079-4573)
- Zhenghao Li (ORCID: https://orcid.org/0009-0003-3588-3923)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dddt.s533551
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00