Ultrasound-detected inflammation and structural changes in the joints, tendons and entheses of patients with cancer who developed arthritis or arthralgia after exposure to immune checkpoint inhibitors
This multicentre study reveals a higher burden of ultrasound-detected changes in ICI-arthritis compared with ICI-arthralgia, with diverse patterns across joints, tendons and entheses in both subtypes. Significant subclinical inflammation suggests that many cases of non-specific ICI-arthralgia may benefit from targeted interventions.
Authors
- Paul Emery (ORCID: https://orcid.org/0000-0002-7429-8482)
- Kerem Abacar (ORCID: https://orcid.org/0000-0002-7668-7924)
- D. Sahin Eroglu (ORCID: https://orcid.org/0000-0003-3558-5400)
- Emilio Filippucci (ORCID: https://orcid.org/0000-0002-7251-7784)
- Melina Yerolatsite (ORCID: https://orcid.org/0009-0007-6325-8649)
- Kulveer Mankia (ORCID: https://orcid.org/0000-0002-7945-6582)
- Jana Hurňáková (ORCID: https://orcid.org/0000-0002-1139-539X)
- Luca Di Geso
- Paraskevi V. Voulgari (ORCID: https://orcid.org/0000-0002-5193-2284)
- Tadashi Okano (ORCID: https://orcid.org/0000-0002-8849-9824)
- Juan José de Agustín (ORCID: https://orcid.org/0000-0001-7702-1625)
- Sana Sharrack (ORCID: https://orcid.org/0009-0004-2436-8229)
- Ernesto Trallero‐Araguás (ORCID: https://orcid.org/0000-0003-3365-4521)
- Andrea Di Matteo (ORCID: https://orcid.org/0000-0003-0867-7051)
- Richard J. Wakefield (ORCID: https://orcid.org/0000-0001-5352-8683)
- Rudolf Horváth (ORCID: https://orcid.org/0000-0001-5787-9990)
- Kate Harnden (ORCID: https://orcid.org/0000-0003-4699-1498)
Institutions
- Marche Polytechnic University (IT)
- University of Leeds (GB)
- University of Ioannina (GR)
- Leeds Teaching Hospitals NHS Trust (GB)
- University Hospital in Motol (CZ)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Ospedale generale di zona San Camillo Treviso (IT)
- Osaka Metropolitan University (JP)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-005879
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00