<i>O</i> -GlcNAc transferase promotes immune evasion and immunotherapy resistance in uterine corpus endometrial cancer by targeting the glucocorticoid receptor
Our findings reveal cross-talk between the HBP, steroid hormone pathway, and tumor immune evasion, and suggest potential strategies for sensitizing UCEC to immunotherapy.
Authors
- Ke‐Qiong Deng (ORCID: https://orcid.org/0000-0003-2406-7456)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-6043-0964)
- Xuemin Song (ORCID: https://orcid.org/0000-0002-1887-8386)
- Ying Zhu (ORCID: https://orcid.org/0000-0001-5247-6324)
- Shuo Rong (ORCID: https://orcid.org/0000-0001-9986-5626)
- Yang Xie (ORCID: https://orcid.org/0000-0003-3792-7662)
- Zhibing Lu (ORCID: https://orcid.org/0000-0002-7950-3465)
- Huanhuan Cai (ORCID: https://orcid.org/0000-0003-3426-8630)
- Chao Xu (ORCID: https://orcid.org/0000-0001-9693-0218)
- Li Liu (ORCID: https://orcid.org/0000-0003-2566-7357)
- Hao Zeng (ORCID: https://orcid.org/0000-0002-2061-6350)
- Shi Liu (ORCID: https://orcid.org/0000-0002-9289-0631)
- Li Zhou (ORCID: https://orcid.org/0000-0002-6736-0057)
- Xiangtai Zeng (ORCID: https://orcid.org/0000-0003-1202-124X)
- Min-chao Dai
Institutions
- Central South University (CN)
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Stomatology Hospital (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Hainan 301 Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-011479
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Wuhan University
- Science and Technology Department of Hubei Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities